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http://35.238.111.86//xmlui/handle/123456789/1884
Title: | Modified BODE index to predict mortality in individuals with COPD: the role of 4-min step test |
Authors: | VIEIRA, Elaine B. DEGANI-COSTA, Luiza H. AMORIM, Beatriz C. OLIVEIRA, Lígia B. MIRANDA-SILVA, Talita SPERANDIO, Priscila C. A. MEDEIROS, Wladimir M. ARBEX, Flávio F. RAMOS, Roberta P. NERY, Luiz E. |
Keywords: | COPD Step test Exercise capacity BODE index 6-min walking distance 6-min walk test |
Issue Date: | 2020 |
Publisher: | Respiratory Care |
Abstract: | The BODE (body mass index, air-flow obstruction, dyspnea, exercise capacity) index is a composite prognostic marker that predicts mortality in COPD. It includes body mass index, air-flow obstruction, dyspnea score, and exercise capacity by using the 6-min walk distance. However, a 30-m-long corridor is necessary to perform the test and this limits its use in clinical practice. Step tests may elicit distinct physiologic responses compared with the 6-min walk test but are easy to perform in the office setting. We sought to investigate whether a 4-min step test would be a suitable surrogate of the 6-min walk test, in a modified BODE step index (simplified BODE index), to predict mortality in COPD. METHODS: Individuals with COPD performed a self-paced 4-min step test, and the simplified BODE index was calculated by replacing the 6-min walk distance by the number of steps climbed. Cutoff values were determined by receiver operating characteristic curve analysis as follows: score 0 for >60 steps; score 1 for 50–60 steps; score 2 for 40–49 steps; and score 3 for <40 steps. RESULTS: A total of 186 individuals with COPD were enrolled from 2011 to 2016 (60% males; mean 6 SD age, 65 6 9 y; mean 6 SD FEV1, 50 6 17 L). There were 36 deaths among the study cohort. The simplified BODE index was a prognostic marker, independent of cardiovascular comorbidities and oxygen desaturation (HR 1.12, confidence interval (CI) [1.03–1.22]). Individuals with simplified BODE index scores 6 7 were at higher risk of death from any cause (P < .001, log-rank test). CONCLUSIONS: This was the first study, to our knowledge, to show that the 4-min step test as a surrogate of exercise capacity in the BODE index (simplified BODE index) is an independent predictor of mortality in COPD and may help to spread its use among practicing physicians. |
URI: | http://35.238.111.86//xmlui/handle/123456789/1884 |
Appears in Collections: | Publicação Professores Link |
Files in This Item:
File | Description | Size | Format | |
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ModifiedBODEindexpredictmortality.pdf | 193.98 kB | Adobe PDF | View/Open |
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